Test Details: Angelman (AS) syndrome is a neurodevelopmental genetic disorder mainly caused by a deletion on 15q11-q13, the uniparental disomy of chromosome 15, or an imprinting defect. Typically, molecular diagnosis of AS is done using methylation-specific PCR (MS-PCR) which provides methylation status information for the 15q11q13 region. The MS-PCR assures a faster, cheaper and more efficient method for the primary diagnosis of the SNRPN gene in cases with AS.