M0094
MLH1 Promoter Hyper methylation
Test Details: MLH1 promoter hyper methylation is common in sporadic microsatellite unstable tumours, including colorectal cancer and endometrial cancer, and is associated with loss of MLH1 protein expression. It is rarely detected in Lynch syndrome (hereditary nonpolyposis colorectal cancer or HNPCC). Therefore, in tumours with high-level microsatellite instability (MSI-H) and/or loss of MLH1 staining by immunohistochemistry, the absence of MLH1 promoter methylation is associated with an increased likelihood of germline mutation in a DNA mismatch repair protein.
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Category
Molecular Genetics
Pre-test Information
Clinical Diagnosis with Histopathology report, Histology and IHC. Clinical history and details required.
Report Delivery
6 working days
Gender
All
Organ
Lymphoid System
MLH1 Promoter Hyper methylation
6500
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