K0025
KRAS Mutation Analysis: Exon 3 (Codon 61)
Test Details: The KRAS mutation, which has been associated with several human cancers including lung adenocarcinomas, pancreatic cancers, gastric cancers, biliary cancers and colorectal cancers, is often an early event in tumorigenesis. The mutation of clinical significance are commonly observed in Exon 3-codon 61 and are frequent in colorectal carcinomas. The impact of KRAS mutation on the efficacy of therapies that target the epidermal growth factor (EGFR) is aimed at identifying the best possible treatments for colon cancer patients. Because patients with KRAS mutant colorectal tumor rarely respond to anti-EGFR monoclonal antibodies such as Erbitux. Testing is required to confirm if the tumor is KRAS wild type before utilizing these therapies. The anti-EGFR therapy in combination with the standard chemotherapy regime, is effective in metastatic colorectal cancer.
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Category
Molecular Genetics
Pre-test Information
Minimum of 20% (as assessed by the pathologist) tumor tissue should be available in each FFPE block/slide. Clinical details and histopathology reports mandatory.
Report Delivery
4 working days
Gender
All
Organ
Multi-Organ
KRAS Mutation Analysis: Exon 3 (Codon 61)
5500
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