Test Details: Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) and Factor V Leiden (FVL) are inherited conditions that increases predisposition to abnormal clotting. The most common variant in the MTHFR gene is MTHFR C677T. The folate metabolism gene mutation detection test helps to evaluate the folate metabolism ability. This test is also used to evaluate the cause of elevated homocysteine levels and to determine the risk of thrombosis or premature cardiovascular disease (CVD).