Test Details: Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). The test is indicated in patients with history of venous thrombosis, thrombosis at different sites, coronary artery disease, stroke of unknown etiology, women with recurrent pregnancy loss, unexplained severe pre-eclampsia, placenta abruption, fetal growth retardation.