M0075
MGMT MSP PCR
Test Details: The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene is a strong predictor for the efficacy of temozolomide chemotherapy and survival periods. Genomic DNA is isolated from paraffin section of glioblastoma tissue and subjected to bisulfite treatment. The modified DNA is subjected to real time methylation specific polymerase chain reaction (MSP) to detect methylation or absence of methylation in promoter region of MGMT gene, using sequence specific primers/probes for amplification of independent hypermethylated and non-methylated MGMT.
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Category
Molecular Genetics
Pre-test Information
Clinical history and Histopathology reports are mandatory.
Report Delivery
4 working days
Gender
All
Organ
Brain
MGMT MSP PCR
5940
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