C0115
Chronic Myeloid Leukemia(CML), (4 markers) FISH
Number of Tests | 4 |
Test Included | BCR-ABL, Iso 17q, del 7, Trisomy 8 |
Test Details: Chronic Myeloid Leukaemia (CML) accounts for 15-20% of the diagnosed cases of leukaemia in adults. Majority of CML are caused by the BCR-ABL1 fusion gene. The identification of different BCR-ABL gene fusion is useful in diagnosis of the disease and monitoring Minimal Residual Disease (MRD) status. Isochromosome 17q is the most frequent genetic abnormality observed during progression of CML and plays a presumably important pathogenic role. In patients receiving TKI (Imatinib) therapy, cytogenetic analysis is still relevant especially in case of cytopenia. Signs of dysplasia with del7 clonal chromosomal abnormalities/Ph negative cells should be considered as a red signal and a switch to alternative treatment be discussed. Trisomy 8 in Ph+ CML patients is frequently observed as a secondary chromosome change and is one of the non-random abnormalities associated with the blastic phase of the disease.
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Category
Cytogenetics
Pre-test Information
Clinical history, CBC report and treatment status of the patient is mandatory.
Report Delivery
4 working days
Gender
All
Organ
Blood / Bone Marrow
Chronic Myeloid Leukemia(CML), (4 markers) FISH
10000
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