Test Details: Antisperm antibodies occur when the body becomes sensitised to sperm. This causes an immune system response that destroys the sperm. There are two main types of anti-sperm antibodies: anti-sperm agglutinating antibodies and anti-sperm immobilizing Antibodies. When a couple has difficulty getting pregnant due to antisperm antibodies, it is known as immunologic infertility. An antisperm antibody test looks for special proteins (antibodies) that fight against a man's sperm in blood, vaginal fluids, or semen. The higher the level of antibody-affected sperm found in the semen, the lower the chance of the sperm fertilizing an egg.