Test Details: Immunohistochemical testing is carried out on biopsy/resected tissue specimen. This testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody. CD30 is normally expressed in activated B, T, and NK cells. One of the major utilities of CD30 in routine immunohistochemistry is to highlight Hodgkin cells and Reed-Sternberg cells of classical Hodgkin lymphoma. CD30 is also a diagnostic marker for anaplastic large cell lymphoma and primary mediastinal large B-cell lymphoma.