Test Details: Human Leukocyte Antigen (HLA) typing is of clinical significance in determining tissue compatibility or HLA matching between donor and recipient transplant patients and also in the assessment of disease associations. Matching the HLA loci is essential for successful transplantation. The International ImMunoGeneTics information system (IMGT)/HLA database is used as reference for HLA A, B, C, DR and DQ typing. HLA A, B, C, DR and DQ typing shows 100% specificity and 100% sensitivity. In sequencing, full gene is covered for Class I (A, B and C). For Class II (DRB1 and DQB1) exons 2-4 are covered including the intronic regions in between. Accurate HLA matching between donor and patient significantly improves overall transplant survival, reduces the incidence and severity of both acute and chronic graft versus host disease (GVHD) thereby, improving the rate of engraftment. This has utmost importance in haematopoietic marrow transplants.