Test Details: Immunohistochemical testing helps to identify specific antigens (proteins) within tissue sections utilizing an antigen-specific antibody. Epithelial membrane antigen (EMA) also known as MUC-1 is a transmembrane glycoprotein composed of cytoplasmic and extracellular domains. EMA is highly expressed in different types of epithelial cells mainly glandular epithelium and neoplasms originating from these epithelial types. EMA is frequently expressed in adenocarcinoma of different origin, anaplastic large cell lymphoma, lymphocyte predominant Hodgkin lymphoma, Epithelioid sarcoma, epithelioid meningioma, choroid plexus tumours, ependymoma, chordoma and parachordoma, plasmacytoma.